TMEM175 plays a crucial role in osteoblast differentiation by regulating lysosomal function and autophagy.

ABSTRACT: Bone provides structural support, enables movement, protects internal organs, regulates calcium and phosphorus levels, and contains bone marrow essential for hematopoiesis. Osteoblasts are specialized cells responsible for bone formation through the secretion of extracellular matrix components. Transmembrane protein 175 (TMEM175), which functions as an endosomal/lysosomal K⁺ channel and a lysosomal H⁺ channel, regulates lysosomal function and autophagy. Despite the recognized importance of lysosomes and autophagy in osteoblast differentiation, the specific role of TMEM175 in osteoblast differentiation has not been revealed. In this study, we investigated whether TMEM175 is associated with human bone mineral density and fracture and examined the role of TMEM175 in oste

SUBMITTER: Lee SH 

PROVIDER: S-EPMC11863496 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature