Universal screening for hyperglycemia in early pregnancy and the risk of adverse pregnancy outcomes.

ABSTRACT:

Introduction

This study aimed to evaluate the screening outcomes in women with hyperglycemia in early pregnancy (fasting plasma glucose [FPG] 5.1-6.9 mmol/L and/or HbA1c 39-46 mmol/mol before 20 weeks of gestation).

Methods

This multicenter retrospective cohort study was conducted in China between 2016 and 2022. In our setting, all women without pregestational diabetes performed both FPG and HbA1c screening at the first prenatal visit. Logistic regression models adjusted for confounders were performed to assess the associations of hyperglycemia in early pregnancy with adverse pregnancy outcomes. Subgroup analyses were explored according to the subsequent diagnosis of gestational diabetes (GDM, with or without).

Results

Of the 42,999 women in the analysis, 2515 (5.8%)

SUBMITTER: Shen L 

PROVIDER: S-EPMC11863529 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature