Comprehensive genomic analysis in sporadic early-onset colorectal adenocarcinoma patients.

ABSTRACT:

Background

The incidence of colorectal cancer (CRC) in young adults has increased worldwide. Our study aimed to evaluate genomic alterations in early-onset (aged 15-39 years) sporadic CRC.

Methods

Formalin-fixed, paraffin-embedded tissue samples from 90 patients with histologically confirmed colorectal adenocarcinoma with proficient mismatch repair status from Siriraj Hospital (Bangkok, Thailand) were extracted. Patients with clinically suspected familial adenomatous polyposis were excluded. A 517-gene mutational analysis was performed by next-generation sequencing using the Oncomine Comprehensive Assay Plus kit. The previously reported molecular data in adult-onset CRC from our group were used as a comparator group.

Results

The five most frequently mutated genes were

SUBMITTER: Ponvilawan B 

PROVIDER: S-EPMC11863557 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature