Nanowire-based squalene oleogel repairs skin photoaging.

ABSTRACT: Long-term exposure to ultraviolet B (UVB) radiation induces the accumulation of free radicals in the skin, resulting in oxidative damage and accelerated aging. As a natural anti-oxidant, squalene has been applied as a cosmetic additive. Nonetheless, the liquid oil state of squalene and its low solubility in water usually limits the practical application of squalene. Recently, phosphotungstate calcium nanowires has been synthesized to gelatinize oily solvents, making it feasible to fabricate stable oleogel formulation containing squalene. Herein, the squalene/phosphotungstate calcium nanowires (Sql/PWC) oleogel has been specifically designed and applied to treat skin photoaging. Such oleogel was comprised of oil-based structures that closely mimic the skin's natural lipids, resulting in enh

SUBMITTER: Yan L 

PROVIDER: S-EPMC11863574 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature