Association of late-life variability in hemoglobin A1C with postmortem neuropathologies.

ABSTRACT:

Introduction

To study the relationship of late-life hemoglobin A1C (A1C) with postmortem neuropathology in older adults with and without diabetes mellitus (DM).

Methods

A total of 990 participants from five cohort studies of aging and dementia with at least two annually-collected A1C measures, who had autopsy. Neuropathologic evaluations documented cerebrovascular disease, Alzheimer's disease (AD), and other pathologies. To evaluate the association of A1C mean and variability (standard deviation [SD]) with neuropathology, we used a series of adjusted regression models.

Results

Participants (mean age at death = 90.8 years; education = 15.8 years; 76% women) had six A1C measurements on average. Mean A1C was associated with greater odds of macroinfarcts (estimate = 0.14;

SUBMITTER: Biswas R 

PROVIDER: S-EPMC11863718 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature