Exploring causal relationship of traumatic brain injury and comorbidities: A Mendelian randomization study.

ABSTRACT:

Background

Previous observational studies demonstrated a link existed between traumatic brain injury (TBI) and cerebral disease and multisystem complications, such as dementia, pneumonia, and gastrointestinal disease, but they could be confused by confounding and reverse causality.

Objective

We aimed to figure out the causal correlation between TBI and the following complications.

Methods

Database concerning TBI and complications from genome-wide association study (GWAS) and two-sample Mendelian randomization (MR) analysis was employed to examine whether TBI was causally associated with the risk of some complications. All the analysis was carried out through R, version 4.3.3.

Results

MR analyses indicated that any dementia has a promotional effect on TBI (OR = 

SUBMITTER: Zhang X 

PROVIDER: S-EPMC11863744 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature