Influences of lead-based perovskite nanoparticles exposure on early development of human retina.

ABSTRACT:

Background

Lead-based perovskite nanoparticles (Pb-PNPs) are widely utilized in the photovoltaic industry. However, due to their poor stability and high water solubility, lead often gets released into the environment, which can negatively impact the development of the central nervous system (CNS). As an extension of the CNS, the effects and mechanisms of Pb-PNPs on human retinal development have remained elusive.

Objectives

We aimed to investigate the effects of Pb-PNPs on human retinal development.

Methods

Human embryonic stem cell-derived three-dimensional floating retinal organoids (hEROs) were established to simulate early retinal development. Using immunofluorescence staining, biological-transmission electron microscopy analysis, inductively coupled plasma-mass s

SUBMITTER: Yang C 

PROVIDER: S-EPMC11863764 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature