Genomic characterization of metastatic patterns in prostate cancer using circulating tumor DNA data from the SCRUM-Japan MONSTAR SCREEN project.

ABSTRACT:

Purpose

Genomic characterization of the predisposition of tumors to metastasize to specific sites has been performed in a few studies using mainly tissue-derived genomes. This nationwide prospective observational study investigated the association between genomic characteristics using circulating tumor DNA (ctDNA), and the synchronous and metachronous metastasis of tumors to specific target organs in advanced prostate cancer.

Methods

Patients with advanced prostate cancer undergoing systemic treatment were included. ctDNA was analyzed using the FoundationOne®Liquid CDx assay at enrollment. Associations between genomic characteristics and metastatic status were examined.

Results

Alterations in the genes MYC, APC, and BRCA2 and the DNA repair, MYC,

SUBMITTER: Shiota M 

PROVIDER: S-EPMC11863810 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature