Gem-TIP as a salvage therapy for pediatric extracranial malignant rhabdoid tumors: insights from a retrospective case series.

ABSTRACT:

Objective

This retrospective case series aimed to provide initial insights into the potential effectsof Gemcitabine (Gem), Nab-paclitaxel, Ifosfamide, and Cisplatin (Gem-TIP) combination therapy in children with relapsed/progressive extracranial malignant rhabdoid tumors (eMRTs).

Methods

A retrospective review of patients treated with Gem-TIP following relapse/progression was conducted. Radiologic responses were assessed using RECIST 1.1 criteria, with supplemental imaging data provided for detailed evaluation. Details of concurrent therapies, including radiotherapy, were documented to better delineate their influence on treatment outcomes.

Results

Ten patients were included, with a median age of 29.5 months at diagnosis. Tumor origins were predominantly renal (8 case

SUBMITTER: Li J 

PROVIDER: S-EPMC11863866 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature