Pre-surgical memory impairment is associated with risk of postoperative cognitive dysfunction in a large geriatric cohort.

ABSTRACT: Some patients undergoing surgical procedures display long-term post-surgery cognitive impairment (post-operative cognitive dysfunction; POCD), which may precipitate progression to dementia. We investigated whether preoperative cognitive impairment defined using specific cognitive tests (Paired-Associates Learning and Spatial-Span from the Cambridge Neuropsychological Test Automated Battery, (CANTAB) was associated with increased risk of POCD. N = 590 patients >65years and a matched control group n=114 comprised the final sample. Patients were classified as impaired if a composite memory-score derived from two tests from the CANTAB test battery (spatial working memory and paired-associate learning) scored 1 SD below norms derived from a normative database. Risk of developing POCD 3 months p

SUBMITTER: Granger KT 

PROVIDER: S-EPMC11863874 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature