Effects of mesenchymal stem cells from different sources on the biological functions of multiple myeloma cells.

ABSTRACT:

Background

The therapeutic benefits of mesenchymal stromal cells (MSCs) are largely dependent on paracrine factors, but the supernatants of the different MSCs may have different effects on multiple myeloma (MM) cells. Therefore, this study compared supernatants of bone marrow-derived mesenchymal stromal cells (BM-MSCs) with umbilical cord wharton's jelly's mesenchymal stem cells (UC-WJ MSCs) in different states (non-senescent and replicative senescence) on the MM cells.

Methods

We extracted human BM-MSCs and UC-WJ MSCs in vitro and used H₂O₂ to induce replicative senescence. Concentrated supernatants from MSCs and senescent MSCs (SMSCs) were added to MM cells. Cell proliferation, the cell cycle, apoptosis, cell migration, tumor stemness factor expressio

SUBMITTER: Li Y 

PROVIDER: S-EPMC11863895 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature