Embryonic and neonatal outcomes following double vitrification/thawing: a systematic review and meta-analysis.

ABSTRACT:

Objectives

This systematic review and meta-analysis aimed to evaluate the impact of double vitrification/thawing (DVT) versus single vitrification/thawing (SVT) on key embryonic and neonatal outcomes.

Data extraction

Information sources included systematic search in PubMed, Scopus, and Cochrane databases up to September 7, 2024. Data from each qualifying study were extracted by two reviewers using a standardized electronic data gathering form.

Data analysis

Mantel-Haenszel odds ratio (MHOR) and mean difference (MD) with 95% confidence intervals (CI) were calculated using both fixed and random-effects models. Subgroup analyses were based on biopsy status, number of biopsy rounds, extended culture between rounds of vitrification, and embryo transfer strategy.

Results

SUBMITTER: Maleki-Hajiagha A 

PROVIDER: S-EPMC11863950 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature