Plasma proteomic biomarkers as mediators or moderators for the association between poor cardiovascular health and white matter microstructural integrity: The UK Biobank study.

ABSTRACT:

Introduction

The plasma proteome's mediating or moderating roles in the association between poor cardiovascular health (CVH) and brain white matter (WM) microstructural integrity are largely unknown.

Methods

Data from 3953 UK Biobank participants were used (40-70 years, 2006-2010), with a neuroimaging visit between 2014 and 2021. Poor CVH was determined using Life's Essential 8 (LE8) and reversing standardized z-scores (LE8_{z _rev}). The plasma proteome was examined as a potential mediator or moderator of LE8_{z _rev}'s effects on quantitative diffusion-weighted magnetic resonance imaging (dMRI) metrics.

Results

LE8_{z_rev} was significantly associated with deteriorated WM microstructural integrity, as reflected by lower

SUBMITTER: Beydoun MA 

PROVIDER: S-EPMC11864230 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature