Systemic induction therapy in patients with locally advanced or node-positive urothelial carcinoma: Evaluating treatment outcomes.

ABSTRACT:

Background

The presence of lymph node metastases in patients with urothelial carcinoma (UC) plays a pivotal role in disease management and prognosis. Patients with locally advanced irresectable or clinically node-positive UC are often considered ineligible for surgery due to the extent of affected lymph nodes. Long term remission or even cure may be achieved in a subset of patients who experience response to systemic induction therapy and consolidative locoregional treatment.

Objective

To assess the pathological response to preoperative systemic induction therapy followed by radical surgery in patients with locally advanced irresectable or clinically node-positive UC.

Methods

Searches were performed until September 2023 in 5 databases (EMBASE, MEDLINE, Web-of-Science,

SUBMITTER: Rutten VC 

PROVIDER: S-EPMC11864233 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature