Antiangiogenic therapy combined with immune checkpoint blockade in urothelial cancer: Systematic review and meta-analysis.

ABSTRACT:

Background

Antiangiogenic therapy had been tested in urothelial cancer (UC) without reaching the clinic.

Objective

We provide a systematic review and meta-analysis of trials to assess efficacy of immune checkpoint inhibitors (ICI) combined with antiangiogenic agents in UC.

Methods

Following PRISMA guidelines, we searched for trials with at least one arm of patients with UC treated with ICI plus antiangiogenics. Data were analyzed with the "meta" package from R using a one-staged frequentist meta-analysis.

Results

After screening 13,708 titles and abstracts, 9 studies were selected for analysis with 14 identified cohorts comprising 621 patients: 448 were ICI-naïve (ICI-N) and 173 were ICI-exposed (ICI-E). The estimated objective response rate (ORR) in all patien

SUBMITTER: Moussa MJ 

PROVIDER: S-EPMC11864237 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature