The causal role of lipids in dementia: A Mendelian randomization study.

ABSTRACT:

Background

Increasing evidence suggests that abnormal lipid metabolism is one of the pathogeneses of dementia. It is necessary to reveal the relationship between lipids and dementia.

Objective

This study used bidirectional two-sample Mendelian randomization to explore the causal relationship between 179 lipid species and the risk of dementia.

Methods

We assessed the causal effects of 179 lipid species and four subtypes of dementia including Alzheimer's disease (AD), vascular dementia (VaD), frontotemporal dementia (FTD), and dementia with Lewy bodies (DLB). Inverse variance weighting, MR-Egger method, weighted median, simple mode, and weighted mode were used to analyze the relationship between lipids and dementia. Cochran's Q, MR-Egger intercept test, and MR-PRESSO te

SUBMITTER: Su B 

PROVIDER: S-EPMC11864250 | biostudies-literature | 2025 Jan-Dec

REPOSITORIES: biostudies-literature