Neuropsychological and clinical indicators of Lewy body and Alzheimer's pathology.

ABSTRACT:

Background

Clinical distinction between Alzheimer's disease (AD) and dementia with Lewy bodies (DLB) poses significant challenges due to pathological comorbidity. Similar ages of onset and overlapping cognitive and psychiatric symptoms can lead to diagnostic inaccuracy and inappropriate treatment recommendations.

Objective

Identify the best combination of clinical and neuropsychological predictors of AD, DLB, and mixed DLB/AD neuropathology in dementia patients.

Methods

Using the National Alzheimer's Coordinating Center dataset, we selected either pure AD (n = 189), DLB (n = 21), or mixed DLB/AD (n = 42) patients on autopsy. Neuropsychological and clinical predictors, including core clinical features of DLB, were entered into multivariable logisti

SUBMITTER: Simpson AJ 

PROVIDER: S-EPMC11864265 | biostudies-literature | 2025 Jan-Dec

REPOSITORIES: biostudies-literature