Glial activation in pain and emotional processing regions in the nitroglycerin mouse model of chronic migraine.

ABSTRACT:

Objective

Our aim was to survey astrocyte and microglial activation across four brain regions in a mouse model of chronic migraine.

Background

Chronic migraine is a leading cause of disability, with higher rates in females. The role of central nervous system neurons and glia in migraine pathophysiology is not fully elucidated. Preclinical studies have shown abnormal glial activation in the trigeminal nucleus caudalis of male rodents. No current reports have investigated glial activation in both sexes in other important brain regions involved with the nociceptive and emotional processing of pain.

Methods

The mouse nitroglycerin model of migraine was used, and nitroglycerin (10 mg/kg) or vehicle was administered every other day for 9 days. Prior to injections on days 1,

SUBMITTER: Cropper HC 

PROVIDER: S-EPMC11864597 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature