Basal ganglia output (entopeduncular nucleus) coding of contextual kinematics and reward in the freely moving mouse.

ABSTRACT: The entopeduncular nucleus (EPN) is often termed as one of the output nuclei of the basal ganglia owing to their highly convergent anatomy. The rodent EPN has been implicated in reward and value coding whereas the primate analog internal Globus Pallidus has been found to be modulated by some movements and in some circumstances. In this study, we sought to understand how the rodent EPN might be coding kinematic, reward, and difficulty parameters, particularly during locomotion. Furthermore, we aimed to understand the level of movement representation: whole-body or specific body parts. To this end, mice were trained in a freely moving two-alternative forced choice task with two periods of displacement (return and go trajectories) and performed electrophysiological recordings together with vi

SUBMITTER: Verma Rodriguez AK 

PROVIDER: S-EPMC11864757 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature