Human CST Stimulates Base Excision Repair to Prevent the Accumulation of Oxidative DNA Damage.

ABSTRACT: CTC1-STN1-TEN1 (CST) is a single-stranded DNA binding protein vital for telomere length maintenance with additional genome-wide roles in DNA replication and repair. While CST was previously shown to function in double-strand break repair and promote replication restart, it is currently unclear whether it has specialized roles in other DNA repair pathways. Proper and efficient repair of DNA is critical to protecting genome integrity. Telomeres and other G-rich regions are strongly predisposed to oxidative DNA damage in the form of 8-oxoguanines, which are typically repaired by the base-excision repair (BER) pathway. Moreover, recent studies suggest that CST functions in the repair of oxidative DNA lesions. Therefore, we tested whether CST interacts with and regulates BER protein activity. H

SUBMITTER: Wysong BC 

PROVIDER: S-EPMC11864811 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature