Causal relationship between hormone levels and lung cancer: a Mendelian randomization study.

ABSTRACT:

Background

Lung cancer is a highly prevalent neoplastic disease in various regions of the world, but the mechanism of its occurrence, development, and metastasis is not clear. Different hormone levels have different potential roles in the occurrence, development, and metastasis of lung cancer, but the association between hormone levels and lung cancer is not clear.

Objective

This study aims to explore the causal relationship between hormone levels and lung cancer using Mendelian randomization. Sensitivity and heterogeneity tests were conducted to ensure the reliability of the results, offering insights into the prevention, diagnosis, and treatment of lung cancer.

Methods

We employed a two-sample Mendelian randomization (MR) analysis using large-scale publicly availabl

SUBMITTER: Feng Z 

PROVIDER: S-EPMC11864934 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature