Skin autonomous antibody production regulates host-microbiota interactions.

ABSTRACT: The microbiota colonizes each barrier site and broadly controls host physiology¹. However, when uncontrolled, microbial colonists can also promote inflammation and induce systemic infection². The unique strategies used at each barrier tissue to control the coexistence of the host with its microbiota remain largely elusive. Here we uncover that, in the skin, host-microbiota symbiosis depends on the ability of the skin to act as an autonomous lymphoid organ. Notably, an encounter with a new skin commensal promotes two parallel responses, both under the control of Langerhans cells. On one hand, skin commensals induce the formation of classical germinal centres in the lymph node associated with immunoglobulin G1 (IgG1) and IgG3 antibody responses. On the other hand, micro

SUBMITTER: Gribonika I 

PROVIDER: S-EPMC11864984 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature