Transcriptomic neuron types vary topographically in function and morphology.

ABSTRACT: Neuronal phenotypic traits such as morphology, connectivity and function are dictated, to a large extent, by a specific combination of differentially expressed genes. Clusters of neurons in transcriptomic space correspond to distinct cell types and in some cases-for example, Caenorhabditis elegans neurons¹ and retinal ganglion cells^2-4-have been shown to share morphology and function. The zebrafish optic tectum is composed of a spatial array of neurons that transforms visual inputs into motor outputs. Although the visuotopic map is continuous, subregions of the tectum are functionally specialized^5,6. Here, to uncover the cell-type architecture of the tectum, we transcriptionally profiled its neurons, revealing more than 60 cell types that are organized in d

SUBMITTER: Shainer I 

PROVIDER: S-EPMC11864986 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature