Functional Connectivity Changes Associated With Depression in Dementia With Lewy Bodies.

ABSTRACT:

Objectives

Depressive symptoms are frequent in the early stages of dementia with Lewy bodies (DLB), and more than half of DLB patients would have a history of depression. Our study sought to investigate the functional connectivity (FC) changes associated with depressive symptoms in prodromal to mild DLB patients compared with controls.

Methods

MRI data were collected from 66 DLB patients and 18 controls. Depression was evaluated with the Mini International Neuropsychiatric Interview. Resting-state FC (rsFC) was investigated with the CONN toolbox using a seed-based approach and both regression and comparison analyses.

Results

Correlations were found between the depression scores and the rsFC between fronto-temporal and primary visual areas in DLB patients (p < 0.05, FD

SUBMITTER: Querry M 

PROVIDER: S-EPMC11865007 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature