Age- and sex-related development of osteosarcopenia in the aging Octodon degus rodent model.

ABSTRACT: The increase in life expectancy in recent years has resulted in a higher incidence of age-related diseases. Among these, osteoporosis and sarcopenia, collectively known as osteosarcopenia, have the most significant impact on the quality of life, general health and frailty in the elderly. As for other age-related diseases, pre-clinical studies on these conditions are primarily limited by the availability of experimental model systems. The Octodon degus (O. degus) is a long-lived diurnal rodent identified as a potential tool in ageing research. However, age-related osteosarcopenia changes have not yet been explored. In this study, male and female O. degus from juvenile to senile ages were used (6 months-7 years old). Changes in the volume of several forelimbs and hindlim

SUBMITTER: Gallo-Soljancic P 

PROVIDER: S-EPMC11865034 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature