Cellular immune responses of bovine polymorphonuclear neutrophils to <i>Calicophoron daubneyi</i>.

ABSTRACT: Calicophoron daubneyi infections have increased in Europe, being more frequent than fasciolosis in some areas. Infection occurs once definitive hosts ingest encysted metacercariae present on vegetation. Following excystation, juvenile flukes penetrate the small intestinal mucosa and migrate into the rumen where adults mature. Throughout the somatic migration, juveniles come across different microenvironments and tissues and encounter host leukocytes. Besides phagocytosis, production of reactive oxygen species (ROS) and degranulation, polymorphonuclear neutrophils also cast neutrophil extracellular traps (NETs), which can entrap several parasite species, including the closely related liver fluke Fasciola hepatica. In this study, we analyzed whether in vitro exposure of

SUBMITTER: Silva LMR 

PROVIDER: S-EPMC11865088 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature