Urine complement analysis implies complement activation is involved in membranous nephropathy.

ABSTRACT:

Background

The onset and progression of membranous nephropathy (MN) have been associated with complement activation, yet the overall characteristics of this activation in the kidneys remain unclear. In our study, we utilized urine proteomic data to investigate the features of complement activation. We examined the relationship between urine complement components and both clinicopathological features and clinical outcomes in patients with MN.

Methods

Differential expression proteins (DEPs) analysis was performed using proteomic data from urine samples collected from 50 patients with MN, 50 patients with IgA nephropathies (IgAN), and 72 healthy controls (HC). Then, Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses were carried out on the DEPs identified in MN.

SUBMITTER: Xu Y 

PROVIDER: S-EPMC11865186 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature