Role of guanylate-binding protein 1 in the proliferation of invasive lung adenocarcinoma cells.

ABSTRACT:

Background

Guanylate-binding protein 1 (GBP1) is involved in the malignant progression of lung adenocarcinoma, particularly in the acquisition of invasive potential. However, its role in tumor proliferation and therapeutic viability in invasive lung adenocarcinomas remains unclear.

Methods

This study included 99 patients with invasive lung adenocarcinoma, excluding those with non-invasive lepidic components, who had undergone complete pulmonary resection. Immunohistochemical staining was performed to examine the presence of GBP1, and its prognostic significance was assessed using uni- and multi-variable Cox regression analyses. Additionally, the expression levels of GBP1 gene and protein levels were evaluated in lung adenocarcinoma cell lines (PC-9, A549, NCI-H322, NCI-H441,

SUBMITTER: Kumada T 

PROVIDER: S-EPMC11865198 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature