Following changes in brain structure and function with multimodal MRI in a year-long prospective study on the development of Type 2 diabetes.

ABSTRACT:

Aims

To follow disease progression in a rat model of Type 2 diabetes using multimodal MRI to assess changes in brain structure and function.

Material and methods

Female rats (n = 20) were fed a high fat/high fructose diet or lab chow starting at 90 days of age. Diet fed rats were given streptozotocin to compromise pancreatic beta cells, while chow fed controls received vehicle. At intervals of 3, 6, 9, and 12 months, rats were tested for changes in behavior and sensitivity to pain. Brain structure and function were assessed using voxel based morphometry, diffusion weighted imaging and functional connectivity.

Results

Diet fed rats presented with elevated plasma glucose levels as early as 3 months and a significant gain in weight by 6 months as compared to contr

SUBMITTER: Wang Y 

PROVIDER: S-EPMC11865244 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature