Exploring non-alcohol-based disinfectant: virucidal efficacy of arginine and Zinc chloride against feline calicivirus.

ABSTRACT:

Introduction

Norovirus, a leading cause of acute gastroenteritis worldwide, is notably stable in the environment due to its non-enveloped nature. In the absence of effective vaccines or treatments, disinfection remains the primary prevention strategy, highlighting the importance of virucidal efficacy in household care products. Conventional effective disinfectants are predominantly alcohol-based, but alcohol is known to pose health risks, such as skin irritation. This study investigates a non-alcohol-based alternative, specifically a combination of Arginine and Zinc chloride (ZnCl₂).

Methods

Utilizing MS2 bacteriophage as a surrogate, we identified a robust combination of arginine and ZnCl₂ that is effective against Feline Calicivirus (FCV), a mammalian

SUBMITTER: Kong Li Ying M 

PROVIDER: S-EPMC11865247 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature