T1-relaxation times along the corticospinal tract as a diagnostic marker in patients with amyotrophic lateral sclerosis.

ABSTRACT:

Background and purpose

In the differential diagnostic workup of amyotrophic lateral sclerosis (ALS), magnetic resonance imaging (MRI) is primarily used to rule out significant differential diagnoses. So far, whole-brain T1-mapping has not been assessed as a diagnostic tool in this patient population.

Methods

We investigated the diagnostic potential of a novel T1-mapping method based on real-time MRI with 0.5 mm in-plane resolution and 4s acquisition time per slice. The study included patients aged 18 to 90 years who met the revised El Escorial criteria for at least possible ALS. T1-relaxation times were measured along the corticospinal tract in predefined regions of interest.

Results

Twenty-nine ALS-patients and 43 control group patients (CG) were included in the stud

SUBMITTER: Dierksen F 

PROVIDER: S-EPMC11865248 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature