Immunological profile of lactate metabolism-related genes in Psoriasis a comprehensive analysis based on bulk and single-cell RNA sequencing data.

ABSTRACT: Psoriasis (Pso) is a chronic erythema squamous disease often accompanied by metabolic abnormalities. Disturbances in lactate metabolism have been observed in the skin of patients with Pso, but the role of lactate metabolism in the pathogenesis of Pso remains unclear. To identify core genes associated with lactate metabolism in Pso, we downloaded and merged two Pso-related datasets (GSE13355, GSE109248) from the GEO database. Through comprehensive analysis, we analyzed the functions associated with these hub genes and the correlation between their expression levels and immune infiltration. Additionally, we explored lactate metabolism-related hub genes in different immune cells using single-cell sequencing data. We identified four lactate metabolism-related hub genes that are highly associat

SUBMITTER: Liu SY 

PROVIDER: S-EPMC11865271 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature