Occlusion of TCR binding to HLA-A*11:01 by a non-pathogenic human alloantibody.

ABSTRACT: Over the last decades, organ transplantation has made rapid progress as a curative therapy for organ failure. However, the adaptive immune system-alloreactive T cells and antibodies targeting human leukocyte antigens (HLA)-is the leading cause of graft rejection. The presence of anti-donor HLA antibodies is considered a risk factor that disqualifies a particular donor-recipient pair. However, alloantibodies are found in some long-term graft survivors, suggesting a protective blocking function of some alloantibodies. Therefore, whether alloantibodies can have a positive as well as a negative effect in transplantation remains unclear. Here, HLA-A*11:01-specific monoclonal antibodies were generated from a human non-immune antibody library, and the effect of these antibodies was investigated o

SUBMITTER: Hamidinia M 

PROVIDER: S-EPMC11865395 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature