Wogonoside alleviates the proliferation and promotes the apoptosis in liver cancer cells by regulating PI3K/Akt signaling pathway.

ABSTRACT:

Introduction

Primary liver cancer is associated with high morbidity and mortality rate. In about 50% of cases, primary liver cancer is related to the phosphoinositide-3-kinase (PI3K)/Akt signaling pathway. Wogonoside is an active component extracted from Scutellaria baicalensis. Its antitumor effects in liver cancer are scarcely known.

Aim

This study explores the correlation between wogonoside and the PI3K/Akt signaling pathway in liver cancer in vitro.

Methods

THLE-2 cells and HepG2 cells were treated with different concentrations of wogonoside to establish low-, medium- and high- dose groups, and the concentration of each dose group was determined by CCK-8 assay. Subsequent experiments were evaluated the viability, proliferation, invasion, wound healing, apoptosis r

SUBMITTER: Li X 

PROVIDER: S-EPMC11865406 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature