Brain connectivity correlates of the impact of a digital intervention for individuals with subjective cognitive decline on depression and IL-18.

ABSTRACT: Late-life depression represents a significant health concern, linked to disruptions in brain connectivity and immune functioning, mood regulation, and cognitive function. This pilot study explores a digital intervention targeting mental health, brain health, and immune functioning in individuals aged 55-60 with subjective cognitive decline, elevated stress and depressive symptoms. Seventeen participants engaged in a two-week intervention comprising spatial cognition, psychological techniques based on mindfulness, attention-training exercises, and cognitive behavioral therapy. Pre-and post-intervention changes in resting-state functional connectivity, inflammation, and psychological health were evaluated. Key findings include: (1) Reduced self-reported depression with a large effect size, (

SUBMITTER: Catalogna M 

PROVIDER: S-EPMC11865443 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature