CD301b⁺ dendritic cell-derived IL-2 dictates CD4⁺ T helper cell differentiation.

ABSTRACT: T helper (Th) cell differentiation is fundamental to functional adaptive immunity. Different subsets of dendritic cells (DC) preferentially induce different types of Th cells, but the DC-derived mechanism for Th type 2 (Th2) differentiation is not fully understood. Here, we show that in mice, CD301b⁺ DCs, a major Th2-inducing DC subset, drive Th2 differentiation through cognate interaction by rapidly inducing IL-2 receptor signalling in CD4⁺ T cells. Mechanistically, CD40 engagement prompts IL-2 production selectively from CD301b⁺ DCs to maximize CD25 expression in CD4⁺ T cells, which instructs the Th2 fate decision, while simultaneously skewing CD4⁺ T cells away from the T follicular helper fate. Moreover, CD301b⁺ DCs utili

SUBMITTER: Tatsumi N 

PROVIDER: S-EPMC11865452 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature