Direct conversion of various phosphate sources to a versatile P-X reagent [TBA][PO₂X₂] via redox-neutral halogenation.

ABSTRACT: Inorganic phosphates hold significant potential as ideal natural building blocks, forming a fundamental basis for organic and biochemical synthesis. However, their limited solubility, inherent chemical stability, and low reactivity pose substantial challenges to converting phosphates into organophosphates under mild conditions. This study introduces an efficient method for the direct conversion of phosphates into P(V)-X reagents, [TBA][PO₂X₂] (X = Cl, F), via a redox-neutral halogenation process. This method utilizes cyanuric chloride (or cyanuric fluoride) as the halogenation reagent, in combination with 1-formylpyrrolidine and tetrabutylammonium chloride (TBAC), under ambient conditions. The approach enables effective halogenation conversion for various P(V) sources

SUBMITTER: Tian Y 

PROVIDER: S-EPMC11865473 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature