Comparative study of cytochrome P450 expression in the kidneys of Lepus yarkandensis and Oryctolagus cuniculus.

ABSTRACT: Lepus yarkandensis is a desert hare of the Tarim Basin in western China, and it has strong adaptability to drought environments. Cytochrome P450s (CYP450s) are important metabolic enzymes, and their metabolites (19-hydroxyeicosatetraenoic acid (19-HETE), 20-HETE, and epoxyeicosatrienoic acids (EETs)) are important for regulating kidney water absorption and sodium excretion. This study aimed to investigate the expression of CYP450 enzymes in the kidneys of L. yarkandensis. Our results revealed significant upregulation of CYP2E1 in L. yarkandensis kidneys compared with Oryctolagus cuniculus kidneys, particularly on the basolateral plasma membrane of proximal convoluted tubule (PCT) and proximal straight tubule (PST) cells, as well as in the outer medullary collecting duct and in the beginnin

SUBMITTER: Zhang J 

PROVIDER: S-EPMC11865575 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature