New nanomanufacturing strategy through bioinspired design, for promising treatment of Parkinson's disease.

ABSTRACT: This study attempts to develop a new nanomanufacturing strategy for Parkinson's disease using natural biodegradable components (chitosan, albumin, and dopamine) that can penetrate the blood-brain barrier (BBB) due to biocompatibility, biodegradability, targeted delivery, and controlled drug release. It was prepared, thoroughly optimized and characterized using various biophysical and chemical techniques. Results showed that the nanomanufactured system (molar ratio of 1:0.25:0.5 and particle size range: 38-190 nm) exhibited a zeta potential of + 73 mV facilitating efficient pentration of BBB through an adsorption mechanism with the cell membrane's negative charges. The particle size of the nanomanufactured system and spherical nanoparticle clusters indicated its ability to enhance dopamine

SUBMITTER: Razzak AA 

PROVIDER: S-EPMC11865579 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature