MiR-16-5p, miR-21-5p, and miR-155-5p in circulating vesicles as psoriasis biomarkers.

ABSTRACT: Psoriasis is a chronic skin disorder marked by fast skin cell growth, leading to thick, red, scaly patches. MicroRNAs are small, non-coding RNA molecules that play a crucial role in post-transcriptional gene regulation. This study investigates miR-16-5p, miR-21-5p, and miR-155-5p expression in psoriasis EVs and assesses their biomarker potential, exploring associated target genes and pathways via bioinformatics. A cross-sectional and case-control study included 40 psoriasis patients, with blood samples collected in EDTA tubes. RNA from extracellular vesicles was isolated using Qiagen kits, and miRNAs were quantified via RT-qPCR. Bioinformatic analysis predicted target genes using databases like miRDB and TargetScan. Gene expression data from GEO was processed, and differentially expressed

SUBMITTER: Guzman-Martin CA 

PROVIDER: S-EPMC11865590 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature