Frequency and Determinants of Flare and Persistently Active Disease in a Large Multinational Prospective Lupus Cohort.

ABSTRACT:

Objective

In contrast to relapsing-remitting patterns, persistently active disease (PAD) is a disease activity pattern in patients with systemic lupus erythematosus (SLE) that is inadequately studied. We sought to identify the frequency and determinants of flare and PAD in SLE.

Methods

Flare was defined using the Safety of Estrogens in Lupus Erythematosus National Assessment version of the Systemic Lupus Erythematosus Disease Activity Index (SELENA-SLEDAI flare index), and PAD was defined as an SLEDAI-2K score of ≥4, excluding serology only, on two or more consecutive visits with a maximum six-month interval. Multivariable logistic regression was used to develop predictive models for flare and PAD, which were tested in an independent validation subset.

Results

Among 3

SUBMITTER: Hao Y 

PROVIDER: S-EPMC11865638 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature