Metabolic Syndrome, Adipokines, and Response to Advanced Therapies in Rheumatoid Arthritis.

ABSTRACT:

Objective

We determined if metabolic syndrome, its components, and adipokines (adiponectin, leptin, and fibroblast growth factor-21) were associated with response to advanced therapies among patients with rheumatoid arthritis (RA).

Methods

This study included participants with RA initiating either tumor necrosis factor inhibitor (TNFi) or non-TNFi biologic therapies from the Comparative Effectiveness Registry to study Therapies for Arthritis and Inflammatory Conditions (CERTAIN) cohort within the CorEvitas registry. Metabolic syndrome was defined according to the National Cholesterol Education Program Adult Treatment Panel III definition. Adipokines were assessed on stored samples from a subsample of responders and nonresponders (n = 200). The primary outcome was the achieve

SUBMITTER: Baker JF 

PROVIDER: S-EPMC11865684 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature