Uptake and metabolization of four sartan drugs by eight different plants: Targeted and untargeted analyses by HPLC-drift-tube-ion-mobility quadrupole time-of-flight mass spectrometry.

ABSTRACT: In this study, we investigated the uptake and metabolization of four drugs (plus the associated prodrugs) from the sartan family by eight edible plants. Growing the plants hydroponically in a medium containing the respective drug, more than 40 phases I and II metabolites derived from the four sartan drugs could be tentatively identified. To demonstrate the suitability of the proposed analytical approach for actual environmental samples, garden cress (Lepidium sativum) selected as a model plant was grown in water drawn from the effluent of two local wastewater treatment plants. Thereby, three of the sartans, namely, olmesartan, candesartan, and valsartan, could be found in the plant extracts at concentrations of 3.1, 10.4, and 14.4 ng g^-1, respectively. Additionally, for candesar

SUBMITTER: Zellner L 

PROVIDER: S-EPMC11865686 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature