Genetic Analysis of Asymptomatic Antinuclear Antibody Production.

ABSTRACT:

Objective

Antinuclear antibodies (ANA) are detected in up to 14% of the population, and many individuals with ANA are asymptomatic. The literature on the genetic contribution to asymptomatic ANA positivity is limited. In this study, we aimed to perform a genome-wide association study of asymptomatic ANA positivity in multiple populations.

Methods

Asymptomatic individuals who were either ANA positive or ANA negative from the All of Us Research Program were included in this study, selecting those with an ANA test performed by immunofluorescence and no evidence of autoimmune disease. Imputation was performed, and a multipopulation meta-analysis including approximately 6 million single-nucleotide polymorphisms (SNPs) was conducted. Genome-wide SNP-based heritability was estimate

SUBMITTER: Hocaoglu M 

PROVIDER: S-EPMC11865687 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature