Effects of lipid membranes on RNA catalytic activity and stability.

ABSTRACT:

Backgound information

RNA plays crucial roles in cellular organization and metabolism, and modulating its activity is essential for maintaining cellular functions. RNA activity, involving both catalytic (ribozymes) and translation processes, is controlled via myriad mechanisms involving different binding partners such as proteins and smaller polar solutes. We previously reported that lipid membranes can directly interact with the artificial R3C ribozyme changing its activity, however, the effect of lipids on naturally occurring ribozymes remains unknown.

Results

Here, we report that both catalytic activity as well as RNA integrity can be controlled by the presence of different lipid membranes. Gel-phase lipid membranes decreased the activity of hepatitis delta virus ribozyme

SUBMITTER: Czerniak T 

PROVIDER: S-EPMC11865690 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature