Evidence of Site-Specific Mucosal Autoantibody Secretion in Rheumatoid Arthritis.

ABSTRACT:

Objective

Anti-citrullinated protein antibodies (ACPA) have been detected in sputum and saliva, indicating that anti-modified protein antibodies (AMPA) can be produced at mucosal sites in patients with rheumatoid arthritis (RA). However, the body's largest mucosal compartment, the gut, has not yet been examined. We therefore investigated the presence of several AMPA (ACPA, anti-carbamylated protein antibodies [anti-CarP], and anti-acetylated protein antibodies [AAPA]) at different mucosal sites, including the intestinal tract.

Methods

Paired fecal/ileal wash, saliva, and serum samples of patients with RA and healthy volunteers were collected in two independent cohorts. Data involving feces were replicated in a third cohort. In these secretions, AMPA were analyzed using in-ho

SUBMITTER: Derksen VFAM 

PROVIDER: S-EPMC11865693 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature