Nuclear stiffness through lamin A/C overexpression differentially modulates chromosomal instability biomarkers.

ABSTRACT:

Background information

Mitosis is crucial for the faithful transmission of genetic material, and disruptions can result in chromosomal instability (CIN), a hallmark of cancer. CIN is a known driver of tumor heterogeneity and anti-cancer drug resistance, thus highlighting the need to assess CIN levels in cancer cells to design effective targeted therapy. While micronuclei are widely recognized as CIN markers, we have recently identified the toroidal nucleus, a novel ring-shaped nuclear phenotype arising as well from chromosome mis-segregation.

Results

Here, we examined whether increasing nuclear envelope stiffness through lamin A/C overexpression could affect the formation of toroidal nuclei and micronuclei. Interestingly, lamin A/C overexpression led to an increase in toroid

SUBMITTER: Bosch-Calvet M 

PROVIDER: S-EPMC11865694 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature