Surfactant-Based Polymer Microchip Electrophoresis of Ciprofloxacin Hydrochloride Monohydrate in Unfiltered Milk With Fluorescence Detection.

ABSTRACT: This work describes a cross-shaped PMMA ME system capable of detecting ciprofloxacin hydrochloride monohydrate (CPFH) in unfiltered milk samples. The cross-shaped PMMA ME system utilizes a BGE consisting primarily of the surface-active agent SDS to solubilize milk fat and improve the zeta potential of the PMMA microchannel surface. A theoretical lumped-element circuit model for cross-shaped ME is introduced in this work to calculate the migration time of CPFH. This manuscript improves the capabilities of PMMA-based ME for CPFH in milk using an SDS-based BGE. The presented ME system has a faster migration time, higher mean output voltage, and thinner full-width at half-maximum than previously reported dairy-based biosensor systems. Most notably, the migration time of the new system is under

SUBMITTER: Leclerc CA 

PROVIDER: S-EPMC11865704 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature