Accrual of Alzheimer's disease pathology as a function of proximity to parental dementia onset.

ABSTRACT:

Introduction

Whether temporal proximity to parental onset of dementia (PPO) can be used to estimate timing of the preclinical stage of sporadic Alzheimer's disease (AD) remains uncertain.

Methods

We investigated cross-sectionally adults aged > 50 without dementia included in the European Prevention of Alzheimer's Dementia (EPAD) study. PPO was tested as a predictor of quantitative levels of cerebrospinal fluid (CSF) β-amyloid (1-42) (Aβ1-42) in those with a parental history of dementia (n = 688) and of phosphorylated tau (p-tau) and EPAD neuropsychological examination (ENE) subscores in an amyloid positive subgroup (n = 226). Possible interactions were explored.

Results

Shorter PPO predicted lower CSF Aβ1-42 level (β = 9.357; T = 4.161; p < 0.001)

SUBMITTER: Ziukelis ET 

PROVIDER: S-EPMC11865705 | biostudies-literature | 2025 Jan-Mar

REPOSITORIES: biostudies-literature