DGKα Enhances Tumorigenic Activity in Bladder Cancer Patients With Chronic Kidney Disease.

ABSTRACT:

Introduction

Chronic kidney disease (CKD) is a risk factor for bladder cancer (BC) and is reportedly involved in its recurrence and progression. This study aimed to determine the molecular mechanisms underlying the development of BC in patients with CKD.

Methods

First, we generated the CKD mouse model according to a unilateral two-stage renal ischemia-reperfusion injury protocol using wild-type C57BL/6 mice. Second, we conducted a molecular functional analysis of DGKα in BC and investigated the contribution of DGKα to cell invasion, migration, and proliferation activity using human BC cell lines.

Results

After confirming elevated serum creatinine levels in mice, the bladder was dissected, and mRNA sequencing of bladder urothelial cells was conducted. Gene expression p

SUBMITTER: Takemoto K 

PROVIDER: S-EPMC11865707 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature